Mexico City International Airport (aka Benito Juarez Airport) is the closest airport to the conference hotel, Hilton Mexico City Reforma. Check out this Medium article about what to expect arriving and departing from this airport.
Uber is a recommended rideshare service for traveling around Mexico City, including to/from the airport. Learn more at the dedicated Uber page for Mexico City airport. In the app, take note of the Puerta (door or gate) closest to you for pickup location.
Authorized taxi stands are available inside Terminal 1 and Terminal 2. You will need to purchase a ticket (estimated 400 pesos or $13-$15) at the stand before getting into a taxi. ATMs are available in the terminals. Give the attendant the hotel address (Hilton Reforma Mexico City, Av. Juárez 70, Colonia Centro, Centro, Cuauhtémoc, 06010 Ciudad de México, CDMX, Mexico) and they will provide you a ticket to take to a licensed taxi. Some folks recommend writing the hotel address on an index card to give to both the taxi stand attendant and driver. The hotel has a official taxis lined up on the street for a return trip to the airport.
You can also hire a driver to take you to the hotel.
The Metro (subway) or Metrobus (buses) are not recommended for getting to/from the airport.
The Metro (subway) and Metrobus systems are an affordable and easy way to get around once you are ready to explore Mexico City. It is recommended to keep all your valuables inside clothing and avoid rush hour.
Uber and other rideshare options are recommended over taxis. Lyft is not available in Mexico City, but other rideshare options include Didi, inDrive, and Cabify. Feel free to download multiple apps so you can compare prices and see which app works best for you.
If you do wish to take a taxi, do not hail one off the street. Always go through a taxi booth to purchase a trip. Authorized taxis are lined up along the hotel and available at many bus terminals.
A Piece of Travel offers suggestions for exploring destinations while considering physical accessibility on their blog.
Here is a list of some pedestrian exclusive areas in Mexico City, including many near the historic district. Below are a few pedestrian streets located in the Historic Center: